Production of aluminium matrix composites

Imperial Users onl

Sagnac effect in a chain of mesoscopic quantum rings

The ability to interferometrically detect inertial rotations via the Sagnac effect has been a strong stimulus for the development of atom interferometry because of the potential 10^{10} enhancement of the rotational phase shift in comparison to optical Sagnac gyroscopes. Here we analyze ballistic transport of matter waves in a one dimensional chain of N coherently coupled quantum rings in the presence of a rotation of angular frequency, \Omega. We show that the transmission probability, T, exhibits zero transmission stop gaps as a function of the rotation rate interspersed with regions of rapidly oscillating finite transmission. With increasing N, the transition from zero transmission to the oscillatory regime becomes an increasingly sharp function of \Omega with a slope \partialT/\partial \Omega N^2. The steepness of this slope dramatically enhances the response to rotations in comparison to conventional single ring interferometers such as the Mach-Zehnder and leads to a phase sensitivity well below the standard quantum limit

Cultural sensitivity in health promotion program: Islamic persuasive communication

Although scenarios in global health are witnessing benefits from new medicines and technologies, nonetheless there are unprecedented reversals. As a result, the World Health Organization has encouraged more innovative approaches in promoting health risk reduction and the reconsideration of risky lifestyle behaviour. The concept of culture sensitivity has emerged as a key topic of interest to health communication. The growing awareness about culture argues both for a shift in the philosophical and theoretical approaches, and in methods underpinning health communication. On the other hand, a lack of understanding of Muslims and their cultural and religious tradition contributes to potential conflicts in health promotion. Thus, based on present study involves health promotion policy makers, implementers, and health practitioners, this paper suggests the use of Islamic values and elements in developing a strategy for communicating health promotion. In specific, this paper has three main objectives: (1) to briefly review the research on cultural sensitivity factor with focus on religious factors in health communication; (2) to discuss what are the values and characteristics that formulate Islamic persuasive communication in general and in health promotion specifically; and (3) to discuss the constrain and challenges of Islamic persuasion in promoting health. This insight may contribute to further development of health promotion strategy for Muslim in Islamic nations as well as Muslim communities in non-Islamic nations through interculturalisation process

Sacred communication: Exploring the attributes of health promotion programs in the faith-based media

Cultural sensitivity is a widely accepted principle among health behaviour and health communication researcher. However, studies that focus on faith-based health communication in particular on Islamic perspective or practices are rare. In contrast, the emergent and increasing of faith based media or communication institutions have significantly marked a growing interest to understand health promotion from cultural sensitivity such as Islamic communication. Thus, based on present study of 13 health promotion programs broadcasted by an Islamic radio station in Malaysia, this paper explored the attributes and practices of the faith based media in promoting health. The 390 minutes length of data was examined by employing thematic analysis using qualitative analysis software-NVivo version 8. In particular, this paper has three objectives: (i) briefly discuss the values and characteristics that formulate Islamic communication in health promotion; (ii) examine the characteristics of Islamic health promotion; and (iii) pointing out the potential and challenges of Islamic health communication in Malaysia. The insight of this paper may contribute to the understanding of Islamic communication in media and its impact for social change agenda such as on health promotion to Muslim community. These findings may also contribute to further development of health promotion strategy for Muslim communities in Islamic nation or non-Islamic nation

Towards the 3D Web with Open Simulator

Continuing advances and reduced costs in computational power, graphics processors and network bandwidth have led to 3D immersive multi-user virtual worlds becoming increasingly accessible while offering an improved and engaging Quality of Experience. At the same time the functionality of the World Wide Web continues to expand alongside the computing infrastructure it runs on and pages can now routinely accommodate many forms of interactive multimedia components as standard features - streaming video for example. Inevitably there is an emerging expectation that the Web will expand further to incorporate immersive 3D environments. This is exciting because humans are well adapted to operating in 3D environments and it is challenging because existing software and skill sets are focused around competencies in 2D Web applications. Open Simulator (OpenSim) is a freely available open source tool-kit that empowers users to create and deploy their own 3D environments in the same way that anyone can create and deploy a Web site. Its characteristics can be seen as a set of references as to how the 3D Web could be instantiated. This paper describes experiments carried out with OpenSim to better understand network and system issues, and presents experience in using OpenSim to develop and deliver applications for education and cultural heritage. Evaluation is based upon observations of these applications in use and measurements of systems both in the lab and in the wild.Postprin

Growing the use of Virtual Worlds in education : an OpenSim perspective

The growth in the range of disciplines that Virtual Worlds support for educational purposes is evidenced by recent applications in the fields of cultural heritage, humanitarian aid, space exploration, virtual laboratories in the physical sciences, archaeology, computer science and coastal geography. This growth is due in part to the flexibility of OpenSim, the open source virtual world platform which by adopting Second Life protocols and norms has created a de facto standard for open virtual worlds that is supported by a growing number of third party open source viewers. Yet while this diversity of use-cases is impressive and Virtual Worlds for open learning are highly popular with lecturers and learners alike immersive education remains an essentially niche activity. This paper identifies functional challenges in terms of Management, Network Infrastructure, the Immersive 3D Web and Programmability that must be addressed to enable the wider adoption of Open Virtual Worlds as a routine learning technology platform. We refer to specific use-cases based on OpenSim and abstract generic requirements which should be met to enable the growth in use of Open Virtual Worlds as a mainstream educational facility. A case study of a deployment to support a formal education curriculum and associated informal learning is used to illustrate key points.Postprin

A Ca2+ Switch Aligns the Active Site of Calpain

AbstractCa2+ signaling by calpains leads to controlled proteolysis during processes ranging from cytoskeleton remodeling in mammals to sex determination in nematodes. Deregulated Ca2+ levels result in aberrant proteolysis by calpains, which contributes to tissue damage in heart and brain ischemias as well as neurodegeneration in Alzheimer's disease. Here we show that activation of the protease core of μ calpain requires cooperative binding of two Ca2+ atoms at two non-EF-hand sites revealed in the 2.1 Å crystal structure. Conservation of the Ca2+ binding residues defines an ancestral general mechanism of activation for most calpain isoforms, including some that lack EF-hand domains. The protease region is not affected by the endogenous inhibitor, calpastatin, and may contribute to calpain-mediated pathologies when the core is released by autoproteolysis

Low tropical diversity during the adaptive radiation of early land plants.

The latitudinal biodiversity gradient, with tropical regions acting as 'evolutionary cradles', is a cornerstone of current biogeographical and ecological theory1. In the modern world floral biodiversity and biomass are overwhelmingly concentrated in the tropics, and it is often assumed that the tropics were evolutionary cradles throughout land plant evolutionary history. For example, the origination and diversification of angiosperms is believed to have taken place in the Cretaceous tropics2 and modern gymnosperms in the Permian tropics3. Here, we show that during the first major diversification of land plants, in the Late Silurian-Early Devonian, land plant biodiversity was much lower at the equator compared to medium-high southern latitudes. Throughout this crucial interval of plant evolution, tropical vegetation remained depauperate and of very low taxonomic biodiversity, although with similar morphological disparity to the more diverse higher latitude floras. Possible explanations for this low tropical floral biodiversity include palaeocontinental configuration or adverse palaeotropical environmental conditions. We discount the possibility that it was simply a fortuitous feature of the biogeographical spread of the earliest vascular land plants.National Geographi

Effects of ACTH, dexamethasone, and adrenalectomy on 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system

Using a highly sensitive quantitative RT-PCR method for the measurement of CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase) mRNAs, we previously demonstrated that CYP11B2 expression in the central nervous system (CNS) is subject to regulation by dietary sodium. We have now quantified the expression of these genes in the CNS of male Wistar Kyoto (WKY) rats in response to systemic ACTH infusion, dexamethasone infusion, and to adrenalectomy. CYP11B1 and CYP11B2 mRNA levels were measured in total RNA isolated from the adrenal gland and discrete brain regions using real-time quantitative RT-PCR. ACTH infusion (40 ng/day for 7 days, N=8) significantly increased CYP11B1 mRNA in the adrenal gland, hypothalamus, and cerebral cortex compared with animals infused with vehicle only. ACTH infusion decreased adrenal CYP11B2 expression but increased expression in all of the CNS regions except the cortex. Dexamethasone (10 μg/day for 7 days, N=8) reduced adrenal CYP11B1 mRNA compared with control animals but had no significant effect on either gene's expression in the CNS. Adrenalectomy (N=6 per group) significantly increased CYP11B1 expression in the hippocampus and hypothalamus and raised CYP11B2 expression in the cerebellum relative to sham-operated animals. This study confirms the transcription of CYP11B1 and CYP11B2 throughout the CNS and demonstrates that gene transcription is subject to differential regulation by ACTH and circulating corticosteroid levels

Hexapeptides from mammalian inhibitory hormone hunt activate and inactivate nematode reproduction

© 2022 Hart et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. https://creativecommons.org/licenses/by/4.0/Background: Biopurification has been used to disclose an evolutionarily conserved inhibitory reproductive hormone involved in tissue mass determination. A (rat) bioassay-guided physicochemical fractionation using ovine materials yielded via Edman degradation a 14-residue amino acid (aa) sequence. As a 14mer synthetic peptide (EPL001) this displayed antiproliferative and reproduction-modulating activity, while representing only a part of the native polypeptide. Even more unexpectedly, a scrambled-sequence control peptide (EPL030) did likewise. Methods: Reproduction has been investigated in the nematode Steinernema siamkayai, using a fermentation system supplemented with different concentrations of exogenous hexapeptides. Peptide structure-activity relationships have also been studied using prostate cancer and other mammalian cells in vitro, with peptides in solution or immobilized, and via the use of mammalian assays in vivo and through molecular modelling. Results: Reproduction increased (x3) in the entomopathogenic nematode Steinernema siamkayai after exposure to one synthetic peptide (IEPVFT), while fecundity was reduced (x0.5) after exposure to another (KLKMNG), both effects being dose-dependent. These hexamers are opposite ends of the synthetic peptide KLKMNGKNIEPVFT (EPL030). Bioactivity is unexpected as EPL030 is a control compound, based on a scrambled sequence of the test peptide MKPLTGKVKEFNNI (EPL001). EPL030 and EPL001 are both bioinformatically obscure, having no convincing matches to aa sequences in the protein databases. EPL001 has antiproliferative effects on human prostate cancer cells and rat bone marrow cells in vitro. Intracerebroventricular infusion of EPL001 in sheep was associated with elevated growth hormone in peripheral blood and reduced prolactin. The highly dissimilar EPL001 and EPL030 nonetheless have the foregoing biological effects in common in mammalian systems, while being divergently pro- and anti-fecundity respectively in the nematode Caenorhabditis elegans. Peptides up to a 20mer have also been shown to inhibit the proliferation of human cancer and other mammalian cells in vitro, with reproductive upregulation demonstrated previously in fish and frogs, as well as nematodes. EPL001 encodes the sheep neuroendocrine prohormone secretogranin II (sSgII), as deduced on the basis of immunoprecipitation using an anti-EPL001 antibody, with bespoke bioinformatics. Six sSgII residues are key to EPL001’s bioactivity: MKPLTGKVKEFNNI. A stereospecific bimodular tri-residue signature is described involving simultaneous accessibility for binding of the side chains of two specific trios of amino acids, MKP & VFN. An evolutionarily conserved receptor is conceptualised having dimeric binding sites, each with ligand-matching bimodular stereocentres. The bioactivity of the 14mer control peptide EPL030 and its hexapeptide progeny is due to the fortuitous assembly of subsets of the novel hormonal motif, MKPVFN, a default reproductive and tissue-building OFF signal.Peer reviewe